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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

In Vivo Imaging of the Diseased Nervous System: An Update

Author(s): Catherine Sorbara, Thomas Misgeld and Martin Kerschensteiner

Volume 18, Issue 29, 2012

Page: [4465 - 4470] Pages: 6

DOI: 10.2174/138161212802502279

Price: $65


Cellular in vivo imaging can reveal the induction, progression and resolution of nervous system pathology in real-time. In this review, we summarize recent research in the field to illustrate how in vivo imaging has enhanced our understanding of a variety of neurological conditions caused by trauma, degeneration, ischemia or inflammation. Finally, we look ahead and discuss how novel biosensors might help us to follow not only the cellular but also the molecular pathogenesis of neurological diseases in vivo.

Keywords: In vivo imaging, multi-photon microscopy, neurodegeneration, neurotrauma, ischemia, neuroinflammation, nervous system, biosensors, cerebral cortex, reactive oxygen species.

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