Abstract
Ubiquitin (Ub) is widely distributed in eukaryotic cells as its name means. There are many kinds of Ub-like proteins (for example, SUMO, NEDD8 and ISG15) and Ub-like domains (UbLs) included in multi-domain proteins. To date, a large number of Ub-binding domains (UBDs), such as UBA, CUE, UIM, ZnF, and Pru, are coming up to us with different affinities to Ub and its homologues. The binding specificities provide the basis for controlling various cellular events as well as for delivering ubiquitinated proteins to proteasome for degradation. Structural details of these UBDs and their complexes with Ub might as well show us the delicate mechanism of Ub recognition and regulation. This review summarizes recent progresses on deciphering the structure-based Ub-binding specificities, which are the importantly fundamental elements in orchestrating the ubiquitination and deubiquitination processes in eukaryotic cells.
Keywords: Ubiquitin, Ubiquitin-binding domain; Ubiquitin-like domain; Binding specificity; Structural basis
Current Protein & Peptide Science
Title:Structural Aspects of Ubiquitin Binding Specificities
Volume: 13 Issue: 5
Author(s): Qing-Shan Fu, Ai-Xin Song and Hong-Yu Hu
Affiliation:
Keywords: Ubiquitin, Ubiquitin-binding domain; Ubiquitin-like domain; Binding specificity; Structural basis
Abstract: Ubiquitin (Ub) is widely distributed in eukaryotic cells as its name means. There are many kinds of Ub-like proteins (for example, SUMO, NEDD8 and ISG15) and Ub-like domains (UbLs) included in multi-domain proteins. To date, a large number of Ub-binding domains (UBDs), such as UBA, CUE, UIM, ZnF, and Pru, are coming up to us with different affinities to Ub and its homologues. The binding specificities provide the basis for controlling various cellular events as well as for delivering ubiquitinated proteins to proteasome for degradation. Structural details of these UBDs and their complexes with Ub might as well show us the delicate mechanism of Ub recognition and regulation. This review summarizes recent progresses on deciphering the structure-based Ub-binding specificities, which are the importantly fundamental elements in orchestrating the ubiquitination and deubiquitination processes in eukaryotic cells.
Export Options
About this article
Cite this article as:
Fu Qing-Shan, Song Ai-Xin and Hu Hong-Yu, Structural Aspects of Ubiquitin Binding Specificities, Current Protein & Peptide Science 2012; 13 (5) . https://dx.doi.org/10.2174/138920312802430581
DOI https://dx.doi.org/10.2174/138920312802430581 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recombinant Secretory Immunoglobulin A in Passive Immunotherapy: Linking Immunology and Biotechnology
Current Pharmaceutical Biotechnology A Review of the Treatment of Psoriasis with Infliximab
Reviews on Recent Clinical Trials Lack of Association between NOD2 rs3135500 and IL12B rs1368439 microRNA Binding Site SNPs and Colorectal Cancer Susceptibility in an Iranian Population
MicroRNA The Neuroscience of Maternal Behaviour
Current Psychiatry Reviews Reshaping the Protein Folding Pathway by Osmolyte via its Effects on the Folding Intermediates
Current Protein & Peptide Science Editorial: The Biologic Era: A Comprehensive Approach for Inflammatory and Immune-mediated Diseases
Current Pharmaceutical Biotechnology Neoangiogenesis Induced by Progenitor Endothelial Cells: Effect of Fucoidan from Marine Algae
Cardiovascular & Hematological Agents in Medicinal Chemistry Treatment Modalities for Hepatocellular Carcinoma
Current Cancer Drug Targets The Use of Mycophenolate Mofetil for the Treatment of Systemic Sclerosis
Endocrine, Metabolic & Immune Disorders - Drug Targets Enantioselective Effects of Chiral Pesticides on their Primary Targets and Secondary Targets
Current Protein & Peptide Science Cardiovascular Effects of Endogenous Estrogen and Hormone Therapy
Current Vascular Pharmacology Genetically Modified Viruses Vaccines by Design
Current Pharmaceutical Biotechnology Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease
Current Pharmaceutical Design Oral and Topical Administration of ROQUETTE Schizochytrium sp. Alleviate Skin Inflammation and Improve Wound Healing in Mice
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Role of FoxP3<sup>+</sup> Treg Cells Mediating Immune Suppression in Leprosy
Current Immunology Reviews (Discontinued) Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles
Medicinal Chemistry Molecular Docking Studies of Novel Arylidene-2, 4-Thiazolidinediones as Potential Aldose Reductase Inhibitors
Letters in Drug Design & Discovery Assessment of Retinal Structural and Functional Characteristics in Eyes with Autoimmune Retinopathy
Current Molecular Medicine The Impact of Microplastic on Human Health
Current Biotechnology Interstitial Cystitis / Painful Bladder Syndrome (IC/PBS) Dilemmas in Diagnosis & Treatment
Current Women`s Health Reviews