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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

SUMOylation in Control of Accurate Chromosome Segregation during Mitosis

Author(s): Jun Wan, Divya Subramonian and Xiang-Dong Zhang

Volume 13, Issue 5, 2012

Page: [467 - 481] Pages: 15

DOI: 10.2174/138920312802430563

Abstract

Posttranslational protein modification by small ubiquitin-related modifier (SUMO) has emerged as an important regulatory mechanism for chromosome segregation during mitosis. This review focuses on how SUMOylation regulates the centromere and kinetochore activities to achieve accurate chromosome segregation during mitosis. Kinetochores are assembled on the specialized chromatin domains called centromeres and serve as the sites for attaching spindle microtubule to segregate sister chromatids to daughter cells. Many proteins associated with mitotic centromeres and kinetochores have been recently found to be modified by SUMO. Although we are still at the early stage of elucidating how SUMOylation controls chromosome segregation during mitosis, a substantial progress has been achieved over the past decade. Furthermore, a major theme that has emerged from the recent studies of SUMOylation in mitosis is that both SUMO conjugation and deconjugation are critical for kinetochore assembly and disassembly. Lastly, we propose a model that SUMOylation coordinates multiple centromere and kinetochore activities to ensure accurate chromosome segregation.

Keywords: Centromere, chromosome segregation, fibrous corona, kinetochore, mitosis, SUMOylation, SUMO interacting motif (SIM), spindle assembly checkpoint (SAC).


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