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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Utility of the Electrocardiogram in Drug Overdose and Poisoning: Theoretical Considerations and Clinical Implications

Author(s): Christopher Yates and Alex F. Manini

Volume 8, Issue 2, 2012

Page: [137 - 151] Pages: 15

DOI: 10.2174/157340312801784961

Price: $65


The ECG is a rapidly available clinical tool that can help clinicians manage poisoned patients. Specific myocardial effects of cardiotoxic drugs have well-described electrocardiographic manifestations. In the practice of clinical toxicology, classic ECG changes may hint at blockade of ion channels, alterations of adrenergic tone, or dysfunctional metabolic activity of the myocardium. This review will offer a structured approach to ECG interpretation in poisoned patients with a focus on clinical implications and ECG-based management recommendations in the initial evaluation of patients with acute cardiotoxicity.

Keywords: Toxicology, electrocardiography, poisoning, electrocardiography, injury-related fatality, ECGs, QRS prolongation, TCA overdose, QT Interval, TCA toxicity, ECG

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