Abstract
Many researchers have tested a hemoglobin (Hb) solution as a possible oxygen carrier after discovering that one Hb molecule contains four hemes that bind and release oxygen reversibly, and that blood type antigens are expressed on the surface of red blood cells (RBCs). However, various side effects emerged during the long development of Hbbased oxygen carriers (HBOCs). The physiological significance of the RBC structure is undergoing reconsideration. Fundamentally, excessive native Hb molecules are toxic, but encapsulation can shield this toxic effect. So-called liposomeencapsulated Hb or Hb-vesicles that mimic the cellular structure of RBCs have been developed for clinical applications.
Keywords: Artificial oxygen carriers, fluid resuscitation, hemoglobin, liposome, transfusion alternative. HBOC, RBC, Hb-vesicles, polymerization, ENCAPSULATEDHB.
Current Drug Discovery Technologies
Title:Present Situation of the Development of Cellular-Type Hemoglobin-Based Oxygen Carrier (Hemoglobin-Vesicles)
Volume: 9 Issue: 3
Author(s): Hiromi Sakai
Affiliation:
Keywords: Artificial oxygen carriers, fluid resuscitation, hemoglobin, liposome, transfusion alternative. HBOC, RBC, Hb-vesicles, polymerization, ENCAPSULATEDHB.
Abstract: Many researchers have tested a hemoglobin (Hb) solution as a possible oxygen carrier after discovering that one Hb molecule contains four hemes that bind and release oxygen reversibly, and that blood type antigens are expressed on the surface of red blood cells (RBCs). However, various side effects emerged during the long development of Hbbased oxygen carriers (HBOCs). The physiological significance of the RBC structure is undergoing reconsideration. Fundamentally, excessive native Hb molecules are toxic, but encapsulation can shield this toxic effect. So-called liposomeencapsulated Hb or Hb-vesicles that mimic the cellular structure of RBCs have been developed for clinical applications.
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Cite this article as:
Sakai Hiromi, Present Situation of the Development of Cellular-Type Hemoglobin-Based Oxygen Carrier (Hemoglobin-Vesicles), Current Drug Discovery Technologies 2012; 9 (3) . https://dx.doi.org/10.2174/157016312802650805
DOI https://dx.doi.org/10.2174/157016312802650805 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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