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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Synthesis, Characterization and Antimicrobial Activity of Pyridine-3- Carbonitrile Derivatives

Author(s): Azza M. Abdel-Fattah, Fawzy A. Attaby, Mohamed A. A. Elneairy and Mohmoud N. M. Gouda

Volume 8, Issue 2, 2012

Page: [176 - 187] Pages: 12

DOI: 10.2174/157340712801784769

Price: $65


2-Cyanoethanethioamide (1) reacted with α,β-unsaturated ketones 2a,b to afford the corresponding 2- thioxopyridine-3-carbonitrile derivatives 6a,b. The reactivity of the latter products towards various chemical reagents was studied to yield both thieno[2,3-b]pyridines 9a-r and 3-aminothieno[2,3-b]pyridine-2-carbohydrazides 10a,b which were used in turn, to prepare N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a,bpyrido[3`,2`:4,5]thieno[3,2- d]pyrimidinones (15a,b,16a,b) and pyrido[3`,2`:4,5]thieno[3,2-d]triazinones 17a,b. Considering the data of IR,1H NMR, mass spectra and elemental analyses the chemical structures of the newly synthesized heterocyclic compounds were elucidated.

Keywords: Pyridothienotriazinones, 2-Cyanoethanethioamide, Pyridothienopyrimidinones, N-phenylmethylenethienopyridin- 2-carbohydrazides, 2-Thioxopyridine-3-carbonitrile, antimicrobial, carbonitrile derivatives, pyridine, heterocyclic compounds, chemical reagents.

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