The Possible Mechanisms for β-glucans to Prevent Atherosclerotic Lesions

Tiphaine      Gislette; Kong-Nan      Zhao; Wenyi      Gu; Jiezhong      Chen

Abstract

Foods enriched in β-glucans including oat and edible fungi as well as some purified β-glucans have been shown to reduce atherosclerotic lesions. The multiple mechanisms may be involved to affect several aspects of the pathogenesis of atherosclerosis such as phagocytosis of macrophages, NO production, epithelial cell functions and blood levels of cholesterol. Structurally different β-glucans may have different effects in the pathogenesis of atherosclerosis. The study of structure-function relationship may provide an approach for optimizing β-glucans to be used in the prevention of atherosclerosis.

Keywords: Atheroslerosis, β-glucans, macrophages, NO production, LDL-cholesterol, Wound healing, phagocytosis, immune resposnes, fungi, plants.