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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Cardioprotective Peptide, Urocortin, Activates Cardiac KATP Channels in Adult Rat.

Author(s): H. Xu, Y. Wang, J. Tao, C. Yang, J. Chen, H. Wang and S. Li

Volume 13, Issue 1, 2006

Page: [21 - 27] Pages: 7

DOI: 10.2174/092986606774502036

Price: $65


Urocortin (UCN), an endogenous cardioprotective peptide, has been reported to activate several ion channels but its effects on the cardiac KATP channels are unknown. In this paper, we showed that adult rat cardiac myocytes had small KATP currents that could be increased 20-fold by pinacidil. UCN also concentration-dependently activated the KATP current and this effect was influenced by ATP and PKA inhibitor peptide, Rp-cAMPS.

Keywords: Urocortin, KATP channel, Pinacidil, Cardiac myocytes, PKA

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