Abstract
Ibuprofen, one of the most widely used non-steroidal anti-inflammatory drug, is an aryl acetic acid derivative, which is an active ingredient in variety of oral formulations such as tablets, gel, pellets, and syrup dosage forms used worldwide. Gastric side effects of ibuprofen are attributed to the presence of free – COOH group and inhibition of endogenous prostaglandins. In recent years, considerable research has been directed at designing prodrugs of ibuprofen with reduced gastro-intestinal toxicity. Numerous ester and amide prodrugs of ibuprofen have been reported. With this background, the present work involves the synthesis, analytical method development, in-vitro hydrolysis, bioanalytical method development, and pharmacokinetics study of an amide prodrug of Ibuprofen coded as TRB-559.
Keywords: Bioanalytical Method Development, Validation, In Vitro Hydrolysis, Pharmacokinetics Study, Non- Steroidal Antiinflammatory Drugs, Analgesic, Prodrug, Prostaglandins, Pharmacokinetics, Drug Release
Current Pharmaceutical Analysis
Title:Synthesis, In Vitro Hydrolysis, Bioanalytical Method Development and Pharmacokinetic Study of an Amide Prodrug of Ibuprofen
Volume: 8 Issue: 3
Author(s): Ritu Ojha, Kunal Nepali, Rohit Goyal, Kanaya Lal Dhar and Tilakraj Bhardwaj
Affiliation:
Keywords: Bioanalytical Method Development, Validation, In Vitro Hydrolysis, Pharmacokinetics Study, Non- Steroidal Antiinflammatory Drugs, Analgesic, Prodrug, Prostaglandins, Pharmacokinetics, Drug Release
Abstract: Ibuprofen, one of the most widely used non-steroidal anti-inflammatory drug, is an aryl acetic acid derivative, which is an active ingredient in variety of oral formulations such as tablets, gel, pellets, and syrup dosage forms used worldwide. Gastric side effects of ibuprofen are attributed to the presence of free – COOH group and inhibition of endogenous prostaglandins. In recent years, considerable research has been directed at designing prodrugs of ibuprofen with reduced gastro-intestinal toxicity. Numerous ester and amide prodrugs of ibuprofen have been reported. With this background, the present work involves the synthesis, analytical method development, in-vitro hydrolysis, bioanalytical method development, and pharmacokinetics study of an amide prodrug of Ibuprofen coded as TRB-559.
Export Options
About this article
Cite this article as:
Ojha Ritu, Nepali Kunal, Goyal Rohit, Lal Dhar Kanaya and Bhardwaj Tilakraj, Synthesis, In Vitro Hydrolysis, Bioanalytical Method Development and Pharmacokinetic Study of an Amide Prodrug of Ibuprofen, Current Pharmaceutical Analysis 2012; 8 (3) . https://dx.doi.org/10.2174/157341212801619333
DOI https://dx.doi.org/10.2174/157341212801619333 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Polymer Structures for Sensors and Actuators 1. Analyte Biosensor
Recent Patents on Materials Science Discovery of Cationic Polymers for Non-Viral Gene Delivery Using Combinatorial Approaches
Combinatorial Chemistry & High Throughput Screening Medical Chemistry to Spy Cancer Stem Cells from Outside the Body
Mini-Reviews in Medicinal Chemistry One-step Separation and Purification of Four Phenolic Acids from Stenoloma chusanum (L.) Ching by Medium-pressure Liquid Chromatography and High-speed Counter-current Chromatography
The Natural Products Journal Expression, Purification, and Antibody Binding Activity of Human Papillomavirus 16 L1 Protein Fused to Maltose Binding Protein
Protein & Peptide Letters The Impact of DIDS-Induced Inhibition of Voltage-Dependent Anion Channels (VDAC) on Cellular Response of Lymphoblastoid Cells to Ionizing Radiation
Medicinal Chemistry Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze)
Cardiovascular & Hematological Disorders-Drug Targets uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy
Current Drug Targets Clinical Proteomics in Cancer Research – Promises and Limitations of Current Two-Dimensional Gel Electrophoresis
Current Medicinal Chemistry The Role of Adenosine in Rheumatoid Arthritis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A Review on Recent Robotic and Analytic Technologies in High Throughput Screening and Synthesis for Drug Discovery
Letters in Drug Design & Discovery Purification and Characterizaion of Buffalo Brain Cystatin
Protein & Peptide Letters Comprehensive Multidimensional Chromatography
Current Chromatography Approaches to Target Profiling of Natural Products
Current Medicinal Chemistry An Overview of Labeled Porphyrin Molecules in Medical Imaging
Recent Patents and Topics on Imaging (Discontinued) Crystal Engineering to Design of Solids: From Single to Multicomponent Organic Materials
Mini-Reviews in Organic Chemistry Cationic <i>Clitoria ternatea</i> Seed Peptide as a Potential Novel Bioactive Molecule
Protein & Peptide Letters Polymer Self-Assembled Nanostructures as Innovative Drug Nanocarrier Platforms
Current Pharmaceutical Design Sequence-Based Prediction of Protein-Protein Interactions by Means of Rotation Forest and Autocorrelation Descriptor
Protein & Peptide Letters Deubiquitinating Enzymes are IN(Trinsic to Proteasome Function)
Current Protein & Peptide Science