Abstract
The scope of this study highlights application of an emerging hybrid vibrational nanoimaging techniques based on surface enhanced nanoimaging microscopy in investigating the inflammatory process in the vascular system and neurodegenerative disorder. The experiments were performed on transgenic rat and ApoE knockout mice model, intravenously injected with USPIO based MR contrast agent. Marked signal enhancement were observed in contrast treated specimens in specific pathological regions, which is known to be infiltrated by helper T cells. The findings were subsequently correlated with the results from MR imaging and immunohistochemistry. The focus of this work encompasses the latest innovation of nanoimaging technology in monitoring the inflammatory process in neurodegenerative diseases, and implementing the first observation of intracellular iron uptakes in the endothelial and medial smooth muscle cells based on Coherent anti-Stokes Raman Scattering (SECARS) Microscopy.
Keywords: ALS, endothelial, nanoimaging, neurodegenerative diseases, smooth muscle cells, USPIO, nanoparticles, SECARS, USPIO, CNS, human SOD-1 gene, neuroinflammation, CEUS, T-lymphocytes, Immunohistochemistry
Current Neurovascular Research
Title:Monitoring the Inflammatory Process by Surface Enhanced Nanoimaging Microscopy
Volume: 9 Issue: 3
Author(s): Lina H. Machtoub
Affiliation:
Keywords: ALS, endothelial, nanoimaging, neurodegenerative diseases, smooth muscle cells, USPIO, nanoparticles, SECARS, USPIO, CNS, human SOD-1 gene, neuroinflammation, CEUS, T-lymphocytes, Immunohistochemistry
Abstract: The scope of this study highlights application of an emerging hybrid vibrational nanoimaging techniques based on surface enhanced nanoimaging microscopy in investigating the inflammatory process in the vascular system and neurodegenerative disorder. The experiments were performed on transgenic rat and ApoE knockout mice model, intravenously injected with USPIO based MR contrast agent. Marked signal enhancement were observed in contrast treated specimens in specific pathological regions, which is known to be infiltrated by helper T cells. The findings were subsequently correlated with the results from MR imaging and immunohistochemistry. The focus of this work encompasses the latest innovation of nanoimaging technology in monitoring the inflammatory process in neurodegenerative diseases, and implementing the first observation of intracellular iron uptakes in the endothelial and medial smooth muscle cells based on Coherent anti-Stokes Raman Scattering (SECARS) Microscopy.
Export Options
About this article
Cite this article as:
H. Machtoub Lina, Monitoring the Inflammatory Process by Surface Enhanced Nanoimaging Microscopy, Current Neurovascular Research 2012; 9 (3) . https://dx.doi.org/10.2174/156720212801618992
DOI https://dx.doi.org/10.2174/156720212801618992 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [Hot Topic: Drug Discovery for CNS Disorders: From Bench to Bedside (Guest Editor: Tiago Fleming Outeiro)]
CNS & Neurological Disorders - Drug Targets <i>Drosophila melanogaster</i> a Versatile Model of Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Are Catechins, Polyphenols in Tea, Good for Your Health?
Current Nutrition & Food Science Mesenchymal Stromal Cells from Umbilical Cord Blood
Current Stem Cell Research & Therapy Editorial [Hot topic: New Therapeutic Strategies for Treatment of Neurodegenerative Diseases (Executive Editor: Aleksey G. Kazantsev)]
Current Pharmaceutical Design Non-Primate EIAV-Based Lentiviral Vectors as Gene Delivery System for Motor Neuron Diseases
Current Gene Therapy Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease
Current Pharmaceutical Design New Strategies for the Synthesis of Bio-medically Relevant Oligosaccharides: Recent Updates on 1,2-cis-O-Glycosylation and α-O-Sialylation
Current Organic Synthesis Control and Role of Plateau Potential Properties in the Spinal Cord
Current Pharmaceutical Design Morphofunctional Aspects of the Blood-Brain Barrier
Current Drug Metabolism Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications
Current Pharmaceutical Design Protein Kinase C Isozymes: Memory Therapeutic Potential
Current Drug Targets - CNS & Neurological Disorders Current Clinical Applications of Botulinum Toxin
Current Pharmaceutical Design HIV-1 Induced CNS Dysfunction: Current Overview and Research Priorities
Current HIV Research Activity-dependent Synaptic Plasticity and Metaplasticity in Spinal Motor Networks
Current Pharmaceutical Design Identification of Inflammatory, Metabolic, and Cell Survival Pathways Contributing to Cerebral Small Vessel Disease by Postmortem Gene Expression Microarray
Current Neurovascular Research CHIP Knockdown Reduced Heat Shock Response and Protein Quality Control Capacity in Lens Epithelial Cells
Current Molecular Medicine Patent Selections:
Recent Patents on Regenerative Medicine GABAergic Pharmacotherapy in the Treatment of Motor Disorders of the Central Nervous System
Current Pharmaceutical Design Are Circulating Monocytes as Microglia Orthologues Appropriate Biomarker Targets for Neuronal Diseases? (Supplementry Table)
Central Nervous System Agents in Medicinal Chemistry