Abstract
Leptin is an adipokine whose proinflammatory properties contribute to the pathogenesis of several autoimmune diseases but also to the development and progression of inflammation in several non-autoimmune inflammatory conditions of the kidney, liver, lung, endometrium, blood vessels and endothelia. Here we review the influences of leptin in those conditions and the pertinent experimental work that has defined some mechanisms of action and/or suggested a therapeutic potential for leptin-based modulation of inflammation in non-autoimmune conditions.
Keywords: Inflammation, leptin, hypothalamic neurons, Th1 and Th2 cytokines, Treg, Teff, STAT, Non-Autoimmune Conditions
Inflammation & Allergy - Drug Targets (Discontinued)
Title:Proinflammatory Activities of Leptin in Non-Autoimmune Conditions
Volume: 11 Issue: 4
Author(s): Antonio La Cava
Affiliation:
Keywords: Inflammation, leptin, hypothalamic neurons, Th1 and Th2 cytokines, Treg, Teff, STAT, Non-Autoimmune Conditions
Abstract: Leptin is an adipokine whose proinflammatory properties contribute to the pathogenesis of several autoimmune diseases but also to the development and progression of inflammation in several non-autoimmune inflammatory conditions of the kidney, liver, lung, endometrium, blood vessels and endothelia. Here we review the influences of leptin in those conditions and the pertinent experimental work that has defined some mechanisms of action and/or suggested a therapeutic potential for leptin-based modulation of inflammation in non-autoimmune conditions.
Export Options
About this article
Cite this article as:
La Cava Antonio, Proinflammatory Activities of Leptin in Non-Autoimmune Conditions, Inflammation & Allergy - Drug Targets (Discontinued) 2012; 11 (4) . https://dx.doi.org/10.2174/187152812800959031
DOI https://dx.doi.org/10.2174/187152812800959031 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
Related Articles
-
Anti-Inflammatory Therapeutic Approaches to Reduce Acute Atherosclerotic Complications
Current Pharmaceutical Biotechnology Withdrawal Notice: Reconnoitering the Role of Endothelin in Obesity
Current Pharmaceutical Design Biologic Therapy in Inflammatory Immunomediated Systemic Diseases: Safety Profile
Current Drug Safety Modulation of Plasma Non Enzimatic Antioxidant Capacity (NEAC) by Plant Foods: the Role of Polyphenol
Current Topics in Medicinal Chemistry Melatonin Role in Experimental Arthritis
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Cardiovascular Disease Burden and Risk Factors Before and After Kidney Transplant
Cardiovascular & Hematological Disorders-Drug Targets MRI of Central Nervous System (CNS) Vasculitis
Current Medical Imaging Currently Used Biologic Agents in the Management of Behcet’s Syndrome
Current Medicinal Chemistry Hypereosinophilic Syndrome, Churg-Strauss Syndrome and Parasitic Diseases: Possible Links between Eosinophilia and Thrombosis
Current Vascular Pharmacology Perspectives on Medicinal Properties of Mangiferin
Mini-Reviews in Medicinal Chemistry Excess Exposure to Insulin Is the Primary Cause of Insulin Resistance and its Associated Atherosclerosis
Current Molecular Pharmacology Pathophysiology of IgG4-Related Disease
Current Immunology Reviews (Discontinued) Commentary: Perivascular Fat and Improved Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Surgery
Current Vascular Pharmacology Antithrombotic Therapy in Cardiac Embolism
Current Cardiology Reviews Understanding Effects of Psychological Stress on Physiology and Disease Through Human Stressome - An Integral Algorithm
Current Bioinformatics Rheumatologic Manifestations of Hematologic Neoplasms
Current Rheumatology Reviews Radiopharmaceuticals in Neurological and Psychiatric Disorders
Current Clinical Pharmacology Drug Targeting of Estrogen Receptor Signaling in the Cardiovascular System: Preclinical and Clinical Studies
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Pediatric CKD and Cardivascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Pharmacological Pre- and Post- Conditioning Agents: Reperfusion-Injury of the Heart Revisited
Mini-Reviews in Medicinal Chemistry