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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Perspectives on the Development of Novel Potentially Active Quinolones Against Tuberculosis and Cancer

Author(s): V. Facchinetti, C. R.B. Gomes, M. V.N. de Souza and T. R.A. Vasconcelos

Volume 12, Issue 9, 2012

Page: [866 - 874] Pages: 9

DOI: 10.2174/138955712800959099

Price: $65


Quinolones and its derivatives comprise an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, antiviral, anti-ischemic, antiparasitic and anxiolytic. Persistent efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side-effects. The present review aims to highlight some recent discoveries on the development of novel quinolone-based compounds with potential antitubercular and anticancer activity.

Keywords: Biological activity, cancer, drugs, quinolones, tuberculosis, iodoanilines, BCG, Ciprofloxacin, in vitro, 6-nitroquinolones

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