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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Targeting Cancer Stem Cells with Natural Products

Author(s): Joseph Burnett, Bryan Newman and Duxin Sun

Volume 13, Issue 8, 2012

Page: [1054 - 1064] Pages: 11

DOI: 10.2174/138945012802009062

Price: $65


The cancer stem cell (CSC) hypothesis presents a fundamentally different paradigm for cancer treatment. CSCs reflect a small fraction of tumor initiating cells capable of sustained self-renewal and differentiation to form the heterogeneous tumor bulk. In order to cure cancer, it is necessary to eliminate cancer stem cells in addition to differentiated cancer cells to decrease metastasis, reduce recurrence, and improve patient survival. In this article, we review cancer stem cell signaling pathways, including Wnt, Hedgehog, and Notch, as well as interactions of CSCs with the tumor microenvironment. We also review methods to isolate CSCs and demonstrate therapeutic efficacy of natural products to modulate these signaling pathways for eliminating CSCs.

Keywords: Akt, cancer stem cell, hedgehog, HIF-1α, natural product, NF-κB, notch, Wnt signaling, tumor, metastasis

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