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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Facile Synthesis of Imidazolidines by Condensation of Aromatic Amines with Glyoxal and Formaldehyde

Author(s): Jian-Qi Zhu, Jia Li, Xin Wang, Ping Fan, Xiao-Nan Wang, Li-Jing Bian, Hao-Qiu Li and Yun-Qi Tian

Volume 16, Issue 14, 2012

Page: [1723 - 1728] Pages: 6

DOI: 10.2174/138527212800840874

Price: $65


By facile condensation of aromatic amines 4-aminobenzoic acid, 2-amino-4, 6-dimethylpyrimidine, 3-aminopyridine, 4- bromobenzenamine and 4-methylbenzenamine with glyoxal and formaldehyde, catalyzed by acid or base under one or two step reaction sequence, five novel (±) trans-4,5-dihydroxy-1,3-diarylimidazolidines (DHDAIs) were prepared and characterized by X-ray single crystal analysis, NMR, IR and elemental analysis.

Keywords: Imidazolidine, Aromatic Amine, Glyoxal, Formaldehyde, Debus-Radziszewski reaction, Heterocyle, DHDAI, Base-catalysis, 3-diarylimidazolidines, 3-aminopyridine

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