Abstract
1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.
Keywords: Anti-inflammatory activity, Antitussive activity, Biological activity, Hydantoin, Ibuprofen, Synthesis
Letters in Drug Design & Discovery
Title:Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives
Volume: 9 Issue: 6
Author(s): Haibin Lu, Dejuan Kong, Bin Wu, Shihan Wang and Yongsheng Wang
Affiliation:
Keywords: Anti-inflammatory activity, Antitussive activity, Biological activity, Hydantoin, Ibuprofen, Synthesis
Abstract: 1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.
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Cite this article as:
Lu Haibin, Kong Dejuan, Wu Bin, Wang Shihan and Wang Yongsheng, Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives, Letters in Drug Design & Discovery 2012; 9 (6) . https://dx.doi.org/10.2174/157018012800673092
DOI https://dx.doi.org/10.2174/157018012800673092 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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