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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives

Author(s): Haibin Lu, Dejuan Kong, Bin Wu, Shihan Wang and Yongsheng Wang

Volume 9, Issue 6, 2012

Page: [638 - 642] Pages: 5

DOI: 10.2174/157018012800673092

Price: $65


1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study, we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed two-fold stronger anti-inflammatory activity than Ibuprofen.

Keywords: Anti-inflammatory activity, Antitussive activity, Biological activity, Hydantoin, Ibuprofen, Synthesis

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