Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis, Antibacterial and Antifungal Activities of 3-Amino-5- methyl[1,1'-biphenyl]-2,4-dicarbonitrile Derivatives

Author(s): Khalid Mohammed Khan, Waqas Jamil, Nida Ambreen, Afroze Amyn, Summaya Saied, Maria Kanwal, Aqeel Ahmed and Shahnaz Perveen

Volume 9, Issue 6, 2012

Page: [618 - 624] Pages: 7

DOI: 10.2174/157018012800672985

Price: $65


3-Amino-5-methyl-2,4-dicarbonitrile biphenyl derivatives 1-14 have been synthesized and all compounds were screened for their antibacterial effects against fourteen Gram-positive and sixteen Gram-negative bacterial strains and showed varying degree of activities. Compounds 1, 2, 4, 5, 6, 8, 13, and 14 were found to be significantly active against various Gram-positive bacteria, however, compounds 1, 3, 4, 6, 9, 12, and 13 were found to be significantly active against various Gram-negative bacterial strains. These compounds were also screened against fourteen fungal strains but showed weak activities against some fungal strains.

Keywords: 3-Amino-5-methyl-2, 4-dicarbonitrile biphenyl derivatives, Antibacterial, Antifungal

Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy