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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Recent Advances in the Medicinal Chemistry of Aurones

Author(s): R. Haudecoeur and A. Boumendjel

Volume 19 , Issue 18 , 2012

Page: [2861 - 2875] Pages: 15

DOI: 10.2174/092986712800672085

Price: $65

Abstract

The first review regarding the potential of aurones as promising drug candidates was reported in 2003. Since, considerable efforts have been made to explore the pharmacological and therapeutical activities of aurones. In this regard, many biological areas were concerned, including major pathological, such as cancer and neurodegenerative disorders. The aim of the present report is to highlight the progress made during the last ten years on the medicinal chemistry of aurones. A special focus will be made on the structure-activity relationship aspects among aurones and especially in case where aurones were found highly active than the corresponding flavones and chalcones.

Keywords: Alzheimer’s disease, antioxidants, aureusidin, antiviral, aurones, cancer, cytotoxicity, flavonoids, hepatitis C, kinases, sulfuretin, tyrosinase


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