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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions

Author(s): Li Li, Haihong Hu, Siyun Xu, Quan Zhou and Su Zeng

Volume 13, Issue 5, 2012

Page: [615 - 623] Pages: 9

DOI: 10.2174/1389200211209050615

Price: $65


UDP-glucuronosyltransferases (UGTs) play important roles in the disposition of many drugs and xenobiotics. Herbal medicine, an important group of multicomponent therapeutics, is widely and increasingly used. Drug metabolism of herbal medicine mediated by cytochrome P450s has been extensively studied; however, herbal medicine metabolism mediated by UGTs has not been adequately investigated. Thus, it is necessary to evaluate current evidence on the glucuronidation of herbal medicines by UGTs. In this review, the research advances of the potential for commonly used herbal medicines as UGT substrate and modulator are summarized. In addition, the herb-drug interactions associated with UGTs are also discussed.

Keywords: UDP-glucuronosyltransferase, herbal medicines, glucuronidation, herb-drug interaction, Phytochemical Metabolism, Associated Herb-Drug Interactions, UGTs, multicomponent therapeutics, Drug metabolism, herbal medicine, cytochrome P450s, glucuronidation, morphine

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