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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Functional Interactions Between B Lymphocytes and the Innate Immune System

Author(s): Vicky Lampropoulou, Ping Shen, Ellen Hilgenberg, Stefanie Ries, Christian Opitz and Simon Fillatreau

Volume 12, Issue 3, 2012

Page: [191 - 199] Pages: 9

DOI: 10.2174/187152612800564374

Price: $65


The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways. Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B cells can contribute to orchestration of humoral and cellular immunity.

Keywords: Autoimmunity, B cells, cytokines, humoral immunity, infections, innate cells, neutrophils, immune system, multiple cell, pathogens, Innate cells, antibody-producing cells, immune responses, cellular immunity, immunological memory

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