A Simple and Effective Approach to the Synthesis of Isoquinoline Derivatives Under Solvent-Free Conditions

Title:A Simple and Effective Approach to the Synthesis of Isoquinoline Derivatives Under Solvent-Free Conditions

Volume: 15 Issue: 6

Author(s): Zinatossadat Hossaini, Faramarz Rostami-Charati, Somayeh Firoziyan, Maryam Sabbaghan and Mohammad A. Khalilzadeh

Affiliation:

Keywords: Indolizine, isoquinoline, one-pot reactions, phenacyl bromides, solvent-free, synthesis, multicomponent reactions, NMR specturm, heterocyclic compounds, reactants

Abstract: An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50oC. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.

Cite this article as:

Hossaini Zinatossadat, Rostami-Charati Faramarz, Firoziyan Somayeh, Sabbaghan Maryam and A. Khalilzadeh Mohammad, A Simple and Effective Approach to the Synthesis of Isoquinoline Derivatives Under Solvent-Free Conditions, Combinatorial Chemistry & High Throughput Screening 2012; 15 (6) . https://dx.doi.org/10.2174/138620712800563909