Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine

Title:Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine

Volume: 15 Issue: 6

Author(s): Kai Wang, Xiaoying Hu, Zhi Wang and Aixia Yan

Affiliation:

Keywords: Acetylcholinesterase inhibitor (AChEI), correlation analysis, F-score, support vector machines (SVM), weka, Alzhemier disease, H-bond, hydrophobiciyty, drug discovery process

Abstract: Acetylcholinesterase has long been considered as a target for Alzheimer disease therapy. In this work, several classification models were built for the purpose of distinguishing acetylcholinesterase inhibitors (AChEIs) and decoys. Each molecule was initially represented by 211 ADRIANA.Code and 334 MOE descriptors. Correlation analysis, F-score and attribute selection methods in Weka were used to find the best reduced set of descriptors, respectively. Additionally, models were built using a Support Vector Machine and evaluated by 5-, 10-fold and leave-one-out cross-validation. The best model gave a Matthews Correlation Coefficient (MCC) of 0.99 and a prediction accuracy (Q) of 99.66% for the test set. The best model also gave good result on an external test set of 86 compounds (Q=96.51%, MCC=0.93). The descriptors selected by our models suggest that H-bond and hydrophobicity interactions are important for the classification of AChEIs and decoys.

Cite this article as:

Wang Kai, Hu Xiaoying, Wang Zhi and Yan Aixia, Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine, Combinatorial Chemistry & High Throughput Screening 2012; 15 (6) . https://dx.doi.org/10.2174/138620712800563891