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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Cerebrovascular Complications of Diabetes: Focus on Stroke

Author(s): Adviye Ergul, Aisha Kelly-Cobbs, Maha Abdalla and Susan C. Fagan

Volume 12, Issue 2, 2012

Page: [148 - 158] Pages: 11

DOI: 10.2174/187153012800493477

Price: $65


Cerebrovascular complications make diabetic patients 2-6 times more susceptible to a stroke event and this risk is magnified in younger individuals and in patients with hypertension and complications in other vascular beds. In addition, when patients with diabetes and hyperglycemia experience an acute ischemic stroke they are more likely to die or be severely disabled and less likely to benefit from the one FDA-approved therapy, intravenous tissue plasminogen activator. Experimental stroke models have revealed that chronic hyperglycemia leads to deficits in cerebrovascular structure and function that may explain some of the clinical observations. Increased edema, neovascularization and protease expression as well as altered vascular reactivity and tone may be involved and point to potential therapeutic targets. Further study is needed to fully understand this complex disease state and the breadth of its manifestation in the cerebrovasculature.

Keywords: Cerebral vasculature, diabetes, hemorrhage, ischemia, stroke, targets

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