Abstract
This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Current Respiratory Medicine Reviews
Title:Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research
Volume: 8 Issue: 2
Author(s): Frank Kramer, Alex Dusek
Affiliation:
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Abstract: This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Export Options
About this article
Cite this article as:
Frank Kramer, Alex Dusek , Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research, Current Respiratory Medicine Reviews 2012; 8(2) . https://dx.doi.org/10.2174/157339812799859770
DOI https://dx.doi.org/10.2174/157339812799859770 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Intra - and Intercellular Calcium Handling in Pulmonary Arterial Hypertension
Medicinal Chemistry Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology The Challenges of Blood Pressure Control in Dialysis Patients
Recent Advances in Cardiovascular Drug Discovery (Discontinued) Renin–Angiotensin–Aldosterone System Gene Polymorphisms and Type 2 Diabetic Nephropathy in Asian Populations: An Updated Meta-analysis
Current Diabetes Reviews Patent Selections
Recent Patents on Anti-Infective Drug Discovery Reducing the Risk of Type 2 Diabetes - Early Identification of High-Risk Individuals and Treatment with Acarbose
Current Diabetes Reviews Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome
Current Medicinal Chemistry ACE2 and Diabetic Complications
Current Pharmaceutical Design Clinical Trials Using Vasodilators in Pulmonary Arterial Hypertension:Where Do We Go from Here?
Reviews on Recent Clinical Trials Dehydrogenases/Reductases for the Synthesis of Chiral Pharmaceutical Intermediates
Current Organic Chemistry The Role of Platelets in Cardiovascular Disease: Molecular Mechanisms
Current Pharmaceutical Design Caffeine as a Lead Compound for the Design of Therapeutic Agents for the Treatment of Parkinson’s Disease
Current Medicinal Chemistry Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments
Current Drug Targets Development of New Therapeutic Agents for Fibrodysplasia Ossificans Progressiva.
Current Molecular Medicine Evaluating the Safety and Tolerability of Azilsartan Medoxomil Alone or in Combination With Chlorthalidone in the Management of Hypertension: A Systematic Review
Current Hypertension Reviews Adipose Tissue Quantification in Rats with the Use of Computed Tomography
Current Medical Imaging Chemical and Biological Aspects of the Genus Verbesina
The Natural Products Journal PDE5 Inhibitors in Non-Urological Conditions
Current Pharmaceutical Design Alzheimer’s Disease and the Early Signs of Age-Related Macular Degeneration
Current Alzheimer Research Drug-Induced Hypokalaemia
Current Drug Safety