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Current Respiratory Medicine Reviews


ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research

Author(s): Frank Kramer, Alex Dusek

Volume 8, Issue 2, 2012

Page: [100 - 107] Pages: 8

DOI: 10.2174/157339812799859770

Price: $65


This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.

Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4

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