An Efficient One Pot Three Component Synthesis of N-(Methylene-4-oxo coumarinyl)anilines; Their Z,E-Isomeric Product Distribution Determination From 1HNMR and their Antibacterial Studies

Title:An Efficient One Pot Three Component Synthesis of N-(Methylene-4-oxo coumarinyl)anilines; Their Z,E-Isomeric Product Distribution Determination From 1HNMR and their Antibacterial Studies

Volume: 9 Issue: 5

Author(s): Abdul Rauf, Hamish McNab, Ashfaq Mahmood Qureshi

Affiliation:

Keywords: coumarins, anti-tumour, chemical shifts, antibacterial, NMR data, micromass analytical machine, d6-DMSO, Z-isomer, E-isomeric product, multicomponent reaction

Abstract: The new series of N-(methylene-4-oxo coumarinyl)anilines 1-13 was synthesised and screening of different solvents led to the discovery of high boiling alcohols as the suitable candidate for one pot efficient three component reaction. Particularly in 2-butanol the product was precipitated out in excellent yields without the hassle of purification. The product distribution of Z and E-isomers was established by 1HNMR. These compounds were screened for their in vitro antibacterial activity against Escherichia Coli, Bacillus Subtilis, Shigella flexenari, Staphylococous aureus, Pseudomonas aeruginosa and Salamonella typhi. Standard drug impenium was used as control.

Cite this article as:

Abdul Rauf, Hamish McNab, Ashfaq Mahmood Qureshi , An Efficient One Pot Three Component Synthesis of N-(Methylene-4-oxo coumarinyl)anilines; Their Z,E-Isomeric Product Distribution Determination From 1HNMR and their Antibacterial Studies, Letters in Drug Design & Discovery 2012; 9 (5) . https://dx.doi.org/10.2174/157018012800389377