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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis and Antitumor Activity of Novel Cis-Furoquinoline Derivatives

Author(s): Jie Li, Shuchen Pei, Yingxi Zhu, Jianbo Wu, Yin Chen, Weiyu Zhang, Yong Wu

Volume 9, Issue 4, 2012

Page: [379 - 388] Pages: 10

DOI: 10.2174/157018012799859909

Price: $65


A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure-activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be potential anticancer agents which deserved further research.

Keywords: Antitumor Activity, Cis-furoquinoline derivatives, c-Kit, Structure-activity relationships (SARs), Synthesis

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