A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives

Fangli Qiu, Jianwei Wu, Yaohong Zhang, Miao Hu, Feng Yu, Guolin Zhang, Yongping Yu

Abstract

A novel synthesis of multisubstituted pyrroles was developed where in trisubstituted olefins were reacted with p-toluenesulfonylmethyl isocyanide (TosMIC) derivatives. The entire process is operationally simplistic and utilizes mild reaction conditions. Additionally a possible mechanism is proposed.

Keywords: p-toluenesulfonylmethyl isocyanide(TosMIC), trisubstituted olefins, multisubstituted pyrrole, heterocycles, derivatives

« Previous Next »