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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Aldose Reductase Inhibitors and Nanodelivery of Diabetic Therapeutics

Author(s): A. M. Prior, M. Thapa, D. H. Hua

Volume 12, Issue 4, 2012

Page: [326 - 336] Pages: 11

DOI: 10.2174/138955712799829294

Price: $65


Nanotechnology is a rapidly emerging drug-delivery system that makes possible the controlled release of small molecules, and nanodelivery of therapeutic molecules using nanoparticles or nanogels represents a major improvement for more focused delivery of such therapeutic molecules. The delivery of insulin for the control of diabetes mellitus (DM) and aldose reductase inhibitor (ARI) for diabetic complications may provide better treatment of diabetes. A structural overview of aldose reductase including computational docking experiments with HAR-1, various ARIs, aldose-keto reductase, and nanodelivery of insulin, ARI's, and drug molecules are described.

Keywords: Aldose reductase, aldose reductase inhibitors, aldo-keto reductase, diabetes, insulin, nanodelivery, nanogels, tricyclic pyrone molecules, sorbitol, dehydrogenase, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, glutathione reductase, glycation, nasal, rectal, pulmonary, microparticles, pre-clinical

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