Abstract
(Pro)renin receptor, (P)RR, exhibited its crucial role in the renin angiotensin (RA) system and also in such organ development as the brain and retina. The binding of (pro)renin to (P)RR mediates the enhanced production of angiotensin-I, which stimulates the tissue-specific RA system and intracellular signal transduction by activating mitogen-activated protein kinase (ERK) 1/2 and p38 pathways. These characteristics together develop the organ damage, especially in diabetes and hypertension. (P)RR acts as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. (P)RR is expressed on the membrane and intracellularly in the golgi apparatus and endoplasmic reticulum. ADAM19 and Furin cleavage sites in the (P)RR molecule have been identified. A soluble form of (P)RR has been detected in the cell culture medium and plasma that can bind renin/prorenin. This review describes recent topics on (pro)renin receptor research in the context of its biochemical and molecular aspects associated with end-stage organ damage.
Keywords: Decoy peptide, “Hinge non-proteolytic activation, peptide, PCP/Fz pathway, prorenin, (pro)renin receptor, renin, V-H+ATPase, Wnt/, β -catenin pathway
18