Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Glutamatergic Animal Models of Schizophrenia

Author(s): Corina Bondi, Marguerite Matthews, Bita Moghaddam

Volume 18, Issue 12, 2012

Page: [1593 - 1604] Pages: 12

DOI: 10.2174/138161212799958576

Price: $65


Dysregulation of glutamate neurotransmission has been implicated in schizophrenia primarily because antagonists of the nmethyl- d-aspartate (NMDA) subtype of glutamate receptors exacerbate preexisting symptoms of schizophrenia in patients and produce behavioral disruptions that resemble some symptoms of schizophrenia in healthy individuals. Given this, NMDA receptor antagonists have been used extensively to model aspects of the disease in laboratory animals and have provided a useful preclinical tool for testing novel treatment strategies. More recent genetic and postmortem findings have implicated proteins other than the NMDA receptor in the pathophysiology of schizophrenia which play a role in regulation of the glutamate synapse. Animal models developed based on these findings have the potential of increasing our mechanistic understanding of the disease. Here we review some of the pertinent literature related to pharmacological and genetic animal models of glutamate dysfunction in schizophrenia.

Keywords: NMDA, DISC1, phencyclidine, antipsychotic drugs, metabotropic glutamate receptors, glutamate neurotransmission, glutamate synapse, genetic animal models, schizophrenia, auditory hallucinations

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy