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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Dual-Layer Wavelet SVM for Predicting Protein Structural Class Via the General Form of Chou’s Pseudo Amino Acid Composition

Author(s): Chao Chen, Zhi-Bin Shen and Xiao-Yong Zou

Volume 19, Issue 4, 2012

Page: [422 - 429] Pages: 8

DOI: 10.2174/092986612799789332


A prior knowledge of protein structural class can provide useful information about its overall structure. So, it is vitally important to develop a computational prediction method for fast and accurately determining the protein structural class. In this paper, a dual-layer wavelet support vector machine (WSVM) is presented via the general form of Chou’s pseudo amino acid composition, which is featured by introducing wavelet as a kernel and making decisions by the fusion from three individual classifiers. As a demonstration, the rigorous jackknife cross-validation tests were performed on two benchmark datasets, including the more challenging 25PDB dataset. Our success rates were reliable, and it has not escaped from our notice that the present method has specific ability to predict the most difficult case of α+β class. The program developed can be acquired freely on request from the authors.

Keywords: Wavelet support vector machine, fusion, protein structural class, pseudo amino acid composition

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