Abstract
Although the zebrafish model provides an important platform for the study of developmental biology, recent work with the zebrafish model has extended its application to a wide variety of experimental studies relevant to human disease. Currently, the zebrafish model is used for the study of human genetic disease, caveolin-associated muscle disease, homeostasis, kidney development and disease, cancer, cardiovascular disorders, oxidative stress, caloric restriction, insulin-like pathways, angiogenesis, neurological diseases, liver disease, hemophilia, bacterial pathogenesis, apoptosis, osteoporosis, immunological studies, germ cell study, Bardet-Biedl syndrome gene (BBS11), Alzheimers disease, virology studies and vaccine development. Here we describe the essential use of the zebrafish model that applies to several clinical diseases. With increased understanding of the cellular mechanisms responsible for disease, we can use knowledge gained from the zebrafish model for the development of therapeutics.
Keywords: Zebrafish, diseases model, disease mechanism, genetic diseases, muscle disease, hemostasis, kidney disease, cancer, cardiovascular disorders, oxidative stress
Current Neurovascular Research
Title: The Zebrafish Model: Use in Studying Cellular Mechanisms for a Spectrum of Clinical Disease Entities
Volume: 4 Issue: 2
Author(s): Chi-Hsin Hsu, Zhi-Hong Wen, Chan-Shing Lin and Chiranjib Chakraborty
Affiliation:
Keywords: Zebrafish, diseases model, disease mechanism, genetic diseases, muscle disease, hemostasis, kidney disease, cancer, cardiovascular disorders, oxidative stress
Abstract: Although the zebrafish model provides an important platform for the study of developmental biology, recent work with the zebrafish model has extended its application to a wide variety of experimental studies relevant to human disease. Currently, the zebrafish model is used for the study of human genetic disease, caveolin-associated muscle disease, homeostasis, kidney development and disease, cancer, cardiovascular disorders, oxidative stress, caloric restriction, insulin-like pathways, angiogenesis, neurological diseases, liver disease, hemophilia, bacterial pathogenesis, apoptosis, osteoporosis, immunological studies, germ cell study, Bardet-Biedl syndrome gene (BBS11), Alzheimers disease, virology studies and vaccine development. Here we describe the essential use of the zebrafish model that applies to several clinical diseases. With increased understanding of the cellular mechanisms responsible for disease, we can use knowledge gained from the zebrafish model for the development of therapeutics.
Export Options
About this article
Cite this article as:
Hsu Chi-Hsin, Wen Zhi-Hong, Lin Chan-Shing and Chakraborty Chiranjib, The Zebrafish Model: Use in Studying Cellular Mechanisms for a Spectrum of Clinical Disease Entities, Current Neurovascular Research 2007; 4 (2) . https://dx.doi.org/10.2174/156720207780637234
DOI https://dx.doi.org/10.2174/156720207780637234 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The beneficial effect of Cape gooseberry juice on carbon tetrachloride-induced neuronal damage
CNS & Neurological Disorders - Drug Targets New-Generation, Non-SSRI Antidepressants: Therapeutic Drug Monitoring and Pharmacological Interactions. Part 1: SNRIs, SMSs, SARIs
Current Medicinal Chemistry Differentiating Normal from Pathological Brain Ageing Using Standard Neuropsychological Tests
Current Alzheimer Research Therapeutic Prospects for the Prevention of Neurodegeneration in Huntingtons Disease and the Polyglutamine Repeat Disorders
Mini-Reviews in Medicinal Chemistry A Novel Non-invasive Effective Method for Potential Treatment of Degenerative Disc Disease: A Hypothesis
Central Nervous System Agents in Medicinal Chemistry Author Index To Volume 3
Current Alzheimer Research Hypertensive Left Ventricular Hypertrophy Regression: Does It Matter?
Current Hypertension Reviews Quorum-Sensing Inhibitors and Biofilms
Anti-Infective Agents in Medicinal Chemistry NAChR α4β2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder
Current Medicinal Chemistry Editorial (Thematic Issue: Recent Progress in Drug Discovery for Parkinson's Disease)
Current Topics in Medicinal Chemistry CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models
Current Gene Therapy Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids
Current Medicinal Chemistry Hydrogen Embrittlement of Zirconium-Based Alloys for Nuclear Fuel Cladding
Innovations in Corrosion and Materials Science (Discontinued) Vitamin D as a Potential Agent for Ischemic Axonal Regeneration after Epineurial Devascularization of the Sciatic Nerve
Current Neurovascular Research Antibody Delivery Mediated by Recombinant Adeno-associated Virus for the Treatment of Various Chronic and Infectious Diseases
Current Gene Therapy Inhibitors of Monoamine Oxidase and Acetylcholinesterase as a Front Runner in CNS Drug Discovery
Combinatorial Chemistry & High Throughput Screening SUBJECT INDEX TO VOLUME 1
Current Drug Safety Synthesis, Characterization, and Molecular Structure of a Novel Zinc (II) Complex: Assessment of Impact of MDR1Pgp Expression on its Cytotoxic Activity
Medicinal Chemistry Medicinal Plants: A Complementary and Alternative Antidepressant Therapy
Current Pharmaceutical Design Rationale for the Development of Cholinesterase Inhibitors as Anti- Alzheimer Agents
Current Pharmaceutical Design