Novel Isocyanide-Based Three-Component Synthesis of Substituted 9Hfuro[ 2,3-f]chromene-8,9-Dicarboxylates in Water

Title:Novel Isocyanide-Based Three-Component Synthesis of Substituted 9Hfuro[ 2,3-f]chromene-8,9-Dicarboxylates in Water

Volume: 15 Issue: 5

Author(s): Faramarz Rostami-Charati, Zinatossadat Hossaini and Mohammad A. Khalilzadeh

Affiliation:

Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, chromene, dialkyl acetylenedicarboxylates, isocyanides, Petasites hybridus, three-component reactions, X-ray diffraction

Abstract: Three-component reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, dialkyl acetylenedicarboxylates and isocyanides in water was described as efficient and green synthetic procedure for preparation of 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in excellent yield. In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)- 1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran. The structure of this compound was determined by 1H, 13C-NMR and IR spectroscopy and confirmed by X-ray diffraction analysis. This procedure provides rapid access to novel and diversely substituted 9H-furo[2,3-f]chromene-8,9-dicarboxylate derivatives....

Cite this article as:

Rostami-Charati Faramarz, Hossaini Zinatossadat and A. Khalilzadeh Mohammad, Novel Isocyanide-Based Three-Component Synthesis of Substituted 9Hfuro[ 2,3-f]chromene-8,9-Dicarboxylates in Water, Combinatorial Chemistry & High Throughput Screening 2012; 15 (5) . https://dx.doi.org/10.2174/138620712800194495