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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

A Clean Procedure for Synthesis of Pyrido[d]Pyrimidine Derivatives Under Solvent-Free Conditions Catalyzed by ZrO2 Nanoparticles

Author(s): Shahrzad Abdolmohammadi and Saeed Balalaie

Volume 15, Issue 5, 2012

Page: [395 - 399] Pages: 5

DOI: 10.2174/138620712800194486

Price: $65


A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3- d]pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an efficient heterogeneous catalyst is described. The procedure has the advantages of high yields (86-97%), short reaction time (2h) and an environmentally friendly specificity....

Keywords: Solvent-free, tandem knoevenagel-michael addition, tetrahydropyrido[d]pyrimidine, ZrO2 nanoparticles

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