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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Mechanism of Adjuvanticity of Aluminium-Containing Formulas

Author(s): Kaat Fierens and Mirjam Kool

Volume 18, Issue 16, 2012

Page: [2305 - 2313] Pages: 9

DOI: 10.2174/138161212800166004

Price: $65

Abstract

Vaccinations have been given to people for at least 100 years of which 80 years formulated in adjuvants. Currently, aluminium- containing formulas and the oil-based substance called MF59 are the two adjuvants licensed for clinical use. Despite the massive use of aluminium adjuvant, its mechanism of action has been only recently addressed. In this review, we will discuss both the cellular and molecular mode of action of aluminium-containing adjuvants.

Keywords: Adjuvant, aluminium hydroxide, dendritic cell, NLRP3, Syk, uric acid and dsDNA


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