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Current Angiogenesis (Discontinued)

Editor-in-Chief

ISSN (Print): 2211-5528
ISSN (Online): 2211-5536

Antibiotics Delay Wound Healing: an Effect Reversed by Co-Administering TLR 7 and 9 Ligands

Author(s): Hiroyasu Ito, Noriho Iida and Dennis M. Klinman

Volume 1 , Issue 1 , 2012

Page: [46 - 51] Pages: 6

DOI: 10.2174/2211552811201010046

Abstract

Pathogenic bacteria are recognized by cells expressing Toll-like receptors (TLRs). This interaction initiates an innate immune response that increases host resistance to infection and accelerates wound healing. This work examines whether antibiotics that eliminate bacteria have a detrimental effect on the rate of wound repair. Results indicate that antibiotic treatment i) eliminates bacteria from the skin, ii) reduces wound inflammation (as manifest by decreased expression of IL-1β, CCL2, IFNα and IFNβ mRNA) and thereby iii) delays wound healing. This adverse consequence is corrected by co-administering the TLR9 ligand CpG ODN and/or the TLR7 ligand imiquimod.

Keywords: CpG oligonucleotide, imiquimod, PAMP, TLR, wound healing


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