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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases

Author(s): H. M. Hugel and N. Jackson

Volume 12, Issue 5, 2012

Page: [380 - 387] Pages: 8

DOI: 10.2174/138955712800493906

Price: $65


Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].

Keywords: EGCG, green tea antioxidants, prooxidants, anti-cancer, neuroprotection, Alzheimer’s disease

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