Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases

H.      M. Hugel; N.      Jackson

Abstract

Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].

Keywords: EGCG, green tea antioxidants, prooxidants, anti-cancer, neuroprotection, Alzheimer’s disease

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