Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Selective Serotonin Reuptake Inhibitors (SSRIs): Therapeutic Drug Monitoring and Pharmacological Interactions

Author(s): R. Mandrioli, L. Mercolini, M. A. Saracino and M. A. Raggi

Volume 19, Issue 12, 2012

Page: [1846 - 1863] Pages: 18

DOI: 10.2174/092986712800099749

Price: $65


New-generation antidepressants are a heterogeneous class of drugs used in the treatment of depression and related disorders. This review deals with the first new-generation antidepressant class to enter the pharmaceutical market, i.e., selective serotonin reuptake inhibitors (SSRIs), which are still the most prescribed and widely used ones. Their common characteristics are the comparable clinical efficacy, good tolerability and relative safety in comparison to “first generation antidepressants”, i.e. classic tricyclic antidepressants and monoamine oxidase inhibitors. This class of drugs includes fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and, since 2011, vilazodone.

In this review, the main pharmacodynamic and pharmacokinetic properties of the six commercially available SSRIs are described, focusing on side and toxic effects, chemical-clinical correlations, interactions with other drugs, the role of therapeutic drug monitoring (TDM) and related bioanalytical methodologies.

Keywords: Antidepressants, chemical-clinical correlations, pharmacological properties, selective serotonin reuptake inhibitors (SSRIs), therapeutic drug monitoring (TDM), fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, vilazodone

Rights & Permissions Print Export Cite as
© 2024 Bentham Science Publishers | Privacy Policy