Abstract
New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.
Keywords: Natural products, tuberculosis, drug development, mycobacterium tuberculosis, drug resistant tuberculosis, structure activity relationship
Current Topics in Medicinal Chemistry
Title:Natural Products as Leads for Tuberculosis Drug Development
Volume: 12 Issue: 7
Author(s): Christine E. Salomon and Lori E. Schmidt
Affiliation:
Keywords: Natural products, tuberculosis, drug development, mycobacterium tuberculosis, drug resistant tuberculosis, structure activity relationship
Abstract: New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.
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Cite this article as:
E. Salomon Christine and E. Schmidt Lori, Natural Products as Leads for Tuberculosis Drug Development, Current Topics in Medicinal Chemistry 2012; 12 (7) . https://dx.doi.org/10.2174/156802612799984526
DOI https://dx.doi.org/10.2174/156802612799984526 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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