Cardiotoxicity of Molecularly Targeted Agents

Nadia      Hedhli; Kerry      S. Russell

Abstract

Cardiac toxicity of molecularly targeted cancer agents is increasingly recognized as a significant side effect of chemotherapy. These new potent therapies may not only affect the survival of cancer cells, but have the potential to adversely impact normal cardiac and vascular function. Unraveling the mechanisms by which these therapies affect the heart and vasculature is crucial for improving drug design and finding alternative therapies to protect patients predisposed to cardiovascular disease. In this review, we summarize the classification and side effects of currently approved molecularly targeted chemotherapeutics.

Keywords: Cardiac toxicity, chemotherapy, cardiomyopathy, tyrosine kinases, proteasome inhibitors.