Generic placeholder image

Current Radiopharmaceuticals


ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Applications of 211At and 223Ra in Targeted Alpha-Particle Radiotherapy

Author(s): Ganesan Vaidyanathan and Michael R. Zalutsky

Volume 4, Issue 4, 2011

Page: [283 - 294] Pages: 12

DOI: 10.2174/1874471011104040283

Price: $65


Targeted radiotherapy using agents tagged with α-emitting radionuclides is gaining traction with several clinical trials already undertaken or ongoing, and others in the advanced planning stage. The most commonly used α-emitting radionuclides are 213Bi, 211At, 223Ra and 225Ac. While each one of these has pros and cons, it can be argued that 211At probably is the most versatile based on its half life, decay scheme and chemistry. On the other hand, for targeting bone metastases, 223Ra is the ideal radionuclide because simple cationic radium can be used for this purpose. In this review, we will discuss the recent developments taken place in the application of 211At-labeled radiopharmaceuticals and give an overview of the current status of 223Ra for targeted α-particle radiotherapy.

Keywords: Alpha-particle radiotherapy, astatine-211, radium-223, alpha-emitting radionuclides, [211At]Astatide, sodium iodide symporter, Meta-[211At]astatobenzylguanidine, MABG, Peptides and Non-Antibody Proteins, Monoclonal Antibodies, 223RADIUM AGENTS

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy