Association Between Polymorphism of SDF1 (CXCL12) Gene and HIV-1 Susceptibility: A Meta-Analysis

SiJie      Liu; HuanZhang      Zhu

Abstract

Studies on the association between SDF1 genotype and HIV-1 susceptibility have generated inconclusive results. Therefore, we conducted a meta-analysis to summarize the findings of different studies. Articles reporting SDF1 gene polymorphisms among HIV-1 infected patients and controls were searched from PubMed up to June 2010. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the association of SDF1 genotype with HIV-1 susceptibility. As a result, 13 studies with 2421 cases and 3283 controls were included in the meta-analysis. Compared with the wild-type SDF1 homozygotes, the pooled OR for SDF1 heterozygotes and SDF1-3A homozygotes were 1.07 (95% CI, 0.79-1.45), 1.38 (95% CI, 0.71-2.69) among exposed uninfected controls and 0.89 (95% CI, 0.75-1.07), 1.15 (95% CI, 0.80-1.63) among healthy controls. In conclusion, no statistically significant association between SDF1 genotype and HIV-1 susceptibility was detected in any models. Our data suggested that SDF1 genotype might have limited effect on HIV-1 susceptibility.

Keywords: SDF1, gene polymorphism, HIV-1 susceptibility, meta-analysis, cellular receptor CD4, CXC chemokine receptor, HIV-1 infection, CXCL12, homozygous individuals, homozygotes