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Current Gene Therapy


ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues

Author(s): Therese Cronin, Thierry Leveillard and Jose-Alain Sahel

Volume 7 , Issue 2 , 2007

Page: [121 - 129] Pages: 9

DOI: 10.2174/156652307780363143

Price: $65


Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review shall focus on the evidence for non-cell-autonomous mechanisms that affect the pattern of degeneration seen in retinal dystrophies, the types of signals that may influence the course of degeneration and finally with the related prospects for retinal-therapies.

Keywords: Signaling, photoreceptor, neuroprotection, retinal degeneration, trophic factors, thioredoxin

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