Abstract
Despite the success of 99mTc-sestamibi and 99mTc-tetrofosmin, the search for 99mTc heart imaging agents having a pharmacokinetic behavior much closer to that of an ideal perfusion tracer has been never interrupted. This short review illustrates advances in this field that have been made using the class of 99mTc complexes characterized by the presence of a terminal technetium-nitrogen multiple bond. This category of 99mTc compounds has proven to be particularly useful for cardiac imaging and a number of highly interesting compounds have been developed. The main chemical and biological properties of these agents are briefly summarized here.
Keywords: Myocardial imaging, Myocardial perfusion, 99mTc nitrido complexes, SPECT
Current Radiopharmaceuticals
Title: The Missed Tc-99m Radiopharmaceuticals for Cardiac Imaging
Volume: 2 Issue: 4
Author(s): Adriano Duatti, Shuang Liu and Roberto Pasqualini
Affiliation:
Keywords: Myocardial imaging, Myocardial perfusion, 99mTc nitrido complexes, SPECT
Abstract: Despite the success of 99mTc-sestamibi and 99mTc-tetrofosmin, the search for 99mTc heart imaging agents having a pharmacokinetic behavior much closer to that of an ideal perfusion tracer has been never interrupted. This short review illustrates advances in this field that have been made using the class of 99mTc complexes characterized by the presence of a terminal technetium-nitrogen multiple bond. This category of 99mTc compounds has proven to be particularly useful for cardiac imaging and a number of highly interesting compounds have been developed. The main chemical and biological properties of these agents are briefly summarized here.
Export Options
About this article
Cite this article as:
Duatti Adriano, Liu Shuang and Pasqualini Roberto, The Missed Tc-99m Radiopharmaceuticals for Cardiac Imaging, Current Radiopharmaceuticals 2009; 2 (4) . https://dx.doi.org/10.2174/1874471010902040268
DOI https://dx.doi.org/10.2174/1874471010902040268 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Therapeutic Targets for Management of Periodontitis and Diabetes
Current Pharmaceutical Design Radionuclide PET and PET/CT in Coronary Artery Disease
Current Pharmaceutical Design Aortic Stenosis, Aortic Regurgitation and Arterial Hypertension
Current Vascular Pharmacology Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation
Current Medicinal Chemistry MRI Contrast Agents: Current Status and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology Left Ventricular Hypertrophy and Angiotensin II Receptor Blocking Agents
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Auraptene: A Natural Biologically Active Compound with Multiple Targets
Current Drug Targets Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases
Current Molecular Medicine Markers of Atherosclerotic Disease: What do they Mean? Current Opinion and Future Trends
Current Pharmaceutical Design Arterial Hypertension and Kidney Circulation
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Antiplatelet and Anticoagulation Strategies in the Prevention and Treatment of Ischemic Stroke
Current Pharmaceutical Design Cardiovascular Effects of Losartan and Its Relevant Clinical Application
Current Medicinal Chemistry Genetic Polymorphism of LDLR (rs688) is Associated with Primary Intracerebral Hemorrhage
Current Neurovascular Research Extra-Hematopoietic Effects of Erythropoietin
Cardiovascular & Hematological Disorders-Drug Targets HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview
Current Drug Metabolism Oxidative Stress and its Clinical Consequences: Relationship between Diabetes and Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Potential of Flavonoids as Anti-inflammatory Agents: Modulation of Pro- Inflammatory Gene Expression and Signal Transduction Pathways
Current Drug Metabolism The Use of Ghrelin and Ghrelin Receptor Agonists as a Treatment for Animal Models of Disease: Efficacy and Mechanism
Current Pharmaceutical Design Atrial Fibrillation in Heart Failure: An Innocent Bystander?
Current Cardiology Reviews