Recent Efforts to Develop Imaging Methods and β -Cell-Specific Contrast Agents for Non-Invasive in vivo Assessment of β-Cell Mass

Title: Recent Efforts to Develop Imaging Methods and β -Cell-Specific Contrast Agents for Non-Invasive in vivo Assessment of β-Cell Mass

Volume: 3 Issue: 3

Author(s): Stephan Schneider, John Virostko, Astrid Reimann and Alvin C. Powers

Affiliation:

Keywords: Non-invasive imaging, β-cell mass, imaging probes, BLI, MRI, PET

Abstract: Accurate, non-invasive assessment of the endogenous pancreatic β-cell mass in humans is currently not feasible. The development of a non-invasive assay of β-cell mass would be invaluable in the study of the natural course of diabetes and ongoing attempts to preserve or restore β-cell mass in patients with diabetes. This article reviews imaging methods and radiolabeled ligands which have been proposed or used for non-invasive assessment of the endogenous β- cell mass and discusses patents and future directions for the development of β-cell specific contrast agents.

Cite this article as:

Schneider Stephan, Virostko John, Reimann Astrid and Powers C. Alvin, Recent Efforts to Develop Imaging Methods and β -Cell-Specific Contrast Agents for Non-Invasive in vivo Assessment of β-Cell Mass, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2009; 3(3) . https://dx.doi.org/10.2174/187221409789104737