Abstract
Accurate, non-invasive assessment of the endogenous pancreatic β-cell mass in humans is currently not feasible. The development of a non-invasive assay of β-cell mass would be invaluable in the study of the natural course of diabetes and ongoing attempts to preserve or restore β-cell mass in patients with diabetes. This article reviews imaging methods and radiolabeled ligands which have been proposed or used for non-invasive assessment of the endogenous β- cell mass and discusses patents and future directions for the development of β-cell specific contrast agents.
Keywords: Non-invasive imaging, β-cell mass, imaging probes, BLI, MRI, PET
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title: Recent Efforts to Develop Imaging Methods and β -Cell-Specific Contrast Agents for Non-Invasive in vivo Assessment of β-Cell Mass
Volume: 3 Issue: 3
Author(s): Stephan Schneider, John Virostko, Astrid Reimann and Alvin C. Powers
Affiliation:
Keywords: Non-invasive imaging, β-cell mass, imaging probes, BLI, MRI, PET
Abstract: Accurate, non-invasive assessment of the endogenous pancreatic β-cell mass in humans is currently not feasible. The development of a non-invasive assay of β-cell mass would be invaluable in the study of the natural course of diabetes and ongoing attempts to preserve or restore β-cell mass in patients with diabetes. This article reviews imaging methods and radiolabeled ligands which have been proposed or used for non-invasive assessment of the endogenous β- cell mass and discusses patents and future directions for the development of β-cell specific contrast agents.
Export Options
About this article
Cite this article as:
Schneider Stephan, Virostko John, Reimann Astrid and Powers C. Alvin, Recent Efforts to Develop Imaging Methods and β -Cell-Specific Contrast Agents for Non-Invasive in vivo Assessment of β-Cell Mass, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2009; 3 (3) . https://dx.doi.org/10.2174/187221409789104737
DOI https://dx.doi.org/10.2174/187221409789104737 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
Physiological Targets for the Treatment of Diabetic Encephalopathy
Central Nervous System Agents in Medicinal Chemistry Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus
Current Drug Targets Gene and Stem Cell Therapy in the Treatment of Erectile Dysfunction and Pulmonary Hypertension; Potential Treatments for the Common Problem of Endothelial Dysfunction
Current Gene Therapy Cyclooxygenase-2 Pathway as a Potential Therapeutic Target in Diabetic Peripheral Neuropathy
Current Drug Targets Current Approach to the Diagnosis and Treatment of Femoral-Popliteal Arterial Disease. A Systematic Review
Current Cardiology Reviews Endothelial Dysfunction in Cardiac Allograft Vasculopathy: Potential Pharmacological Interventions
Current Vascular Pharmacology Failure of Immune Homeostasis - The Consequences of Under and Over Reactivity
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Aldose Reductase Inhibitory Potential of Several Thiazolyl-thiazolidine- 2,4-Diones
Letters in Drug Design & Discovery Intratubular Renin-Angiotensin System in Hypertension
Current Hypertension Reviews Choice of Antihypertensive Treatment in Subjects with Pre-Diabetes. Is There a Dream After the Navigator
Current Vascular Pharmacology Extract of <i>Moringa concanensis</i> Nimmo Leaves Ameliorates Hyperglycemia and Oxidative Stress, and Improves β-cell Function in Alloxan Monohydrate Induced Diabetic Rats
Current Bioactive Compounds Nutrition Transition and Obesity Among Teenagers and Young Adults in South Asia
Current Diabetes Reviews Mechanisms and Inhibitors of Apoptosis in Cardiovascular Diseases
Current Pharmaceutical Design Sodium Selenite as an Anticancer Agent
Anti-Cancer Agents in Medicinal Chemistry The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases
CNS & Neurological Disorders - Drug Targets Molecular Based Drug Targets for Idiopathic Pulmonary Fibrosis
Current Respiratory Medicine Reviews New therapeutic effects of cilostazol in patients with ischemic disorders
Current Vascular Pharmacology Effects of Metabolic Approach in Diabetic Patients with Coronary Artery Disease
Current Pharmaceutical Design Surrogate Outcomes for Progression in the Initial Stages of Diabetic Retinopathy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease
Current Vascular Pharmacology