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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Differences in Lopinavir Plasma Concentrations Comparing Kaletra® Film Coated Tablets and Soft Gelatine Capsules That Result in Various Lipid Abnormalities

Author(s): Judit Morello, Vincent Soriano, Francisco Blanco, Antonio J. Rubio, Inmaculada Jimenez-Nacher and Sonia Rodriguez-Novoa

Volume 3, Issue 2, 2009

Page: [67 - 69] Pages: 3

DOI: 10.2174/187231209788654036

Price: $65


Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.

Keywords: Lopinavir, pharmacokinetics, metabolic complications, dislipidemia, cardiovascular risk, HIV

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