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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Reversal of Major Genotypic Tipranavir Mutations Under Long-Term Treatment with Tipranavir/Ritonavir Itself with Very Limited Optimized Background, During Deep Salvage Antiretroviral Therapy

Author(s): Sergio Sabbatani, Roberto Manfredi, Ciro Fulgaro and Isabella Bon

Volume 7, Issue 3, 2009

Page: [311 - 313] Pages: 3

DOI: 10.2174/157016209788347994

Price: $65

Abstract

A reversal of key HIV protease mutations against tipranavir has been observed in a patient undergoing a late salvage antiretroviral therapy. Our patient initially introduced tipranavir/ritonavir in absence of an optimized background and novel drug classes, and nevertheless he experienced a virological-immunological benefit. Our report is a contribution to the present debate around the role of each single HIV protease mutation, and the validation of mutational “scores” (like the so-called tipranavir weighted score), to be applied to last-generation protease inhibitor compounds initially targeted on patients with limited, residual therapeutic options.

Keywords: Antiretroviral therapy, tipranavir, genotypic mutations, reversal of key mutations, tipranavir mutation score, salvage antiretroviral therapy


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