HIV-1 Vpr: Regulator of Viral Survival

Title: HIV-1 Vpr: Regulator of Viral Survival

Volume: 7 Issue: 2

Author(s): Khanh P. Thieu, Matthew P. Morrow, Devon J. Shedlock, Kimberly A. Schoenly, Karthikbabu Mallilankaraman, Andrew Y. Choo, Paolo Fagone, David B. Weiner and Karuppiah Muthumani

Affiliation:

Keywords: HIV-1, viral protein R (Vpr), viral transcription, apoptosis, cell cycle arrest, mitochondrial membrane potential and immune suppression

Abstract: The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from longterm nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.

Cite this article as:

Thieu P. Khanh, Morrow P. Matthew, Shedlock J. Devon, Schoenly A. Kimberly, Mallilankaraman Karthikbabu, Choo Y. Andrew, Fagone Paolo, Weiner B. David and Muthumani Karuppiah, HIV-1 Vpr: Regulator of Viral Survival, Current HIV Research 2009; 7 (2) . https://dx.doi.org/10.2174/157016209787581454