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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance

Author(s): Chikako Nakai-Murakami, Yuzuru Minemoto and Yukihito Ishizaka

Volume 7, Issue 2, 2009

Page: [109 - 113] Pages: 5

DOI: 10.2174/157016209787581391

Price: $65

Abstract

We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.

Keywords: HIV-1, Vpr, DNA double-strand breaks, ATM, homologous recombination, non-AIDS-defining cancers

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