Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance

Title: Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance

Volume: 7 Issue: 2

Author(s): Chikako Nakai-Murakami, Yuzuru Minemoto and Yukihito Ishizaka

Affiliation:

• Department of Intractable Diseases, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinuku-ku, Tokyo 162-8655, Japan.,Japan

Keywords: HIV-1, Vpr, DNA double-strand breaks, ATM, homologous recombination, non-AIDS-defining cancers

Abstract: We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.

Cite this article as:

Nakai-Murakami Chikako, Minemoto Yuzuru and Ishizaka Yukihito, Vpr-Induced DNA Double-Strand Breaks: Molecular Mechanism and Biological Relevance, Current HIV Research 2009; 7(2) . https://dx.doi.org/10.2174/157016209787581391