Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability

Title: Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability

Volume: 2 Issue: 4

Author(s): Karel Allegaert, Isabelle Scheers, Veerle Cossey and Brian J. Anderson

Affiliation:

Keywords: Ontogeny, renal drug clearance, amikacin, covariates, predictability

Abstract: An earlier reported population pharmacokinetic study documented limited predictability of amikacin clearance (65%) at birth. An exercise in the first month of life resulted in extended predictability (92%) with similar clearance estimates after the first postnatal days, reflecting the impact of postnatal age on clearance predictability.

Cite this article as:

Allegaert Karel, Scheers Isabelle, Cossey Veerle and Anderson J. Brian, Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability, Drug Metabolism Letters 2008; 2 (4) . https://dx.doi.org/10.2174/187231208786734157