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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Identification of Four Urea Adducts of Andrographolide in Humans

Author(s): Liang Cui, Wan Chan, Feng Qiu, Zongwei Cai and Xinsheng Yao

Volume 2, Issue 4, 2008

Page: [261 - 268] Pages: 8

DOI: 10.2174/187231208786734148

Price: $65


Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Keywords: Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS

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